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academy biomed/[A17]兔抗MDA（丙二醛）多克隆抗体，30%甘油/0.5 mg/MD20A-R1a
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academy biomed/[A17]兔抗MDA（丙二醛）多克隆抗体，30%甘油/0.5 mg/MD20A-R1a
商品编号：
MD20A-R1a
品牌：
academybiomed
市场价：
¥8820.00
美元价：
4410.00
产品分类：
其他分子产品
公司分类：
Other_molecular_products
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Host Species: | Rabbit |
| Concentration: | 1 mg/ml (OD 1.35 / 280 nm) |
| Antigen: | MDA-KLH |
| Purification: | Affinity purified |
| Buffer: | 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 |
| Specificity | Specifically binds to MDA-LDL and other MDA modified proteins. Dilution for immunoblot and ELISA range: 1,000 to 20,000. (A slight amount of precipitation may have occurred during storage due to the natural properties of these antibodies; please centrifuge before use.) |
| Use: | The antibody can be used for detection of MDA in plasma, lipoproteins and other MDA modified proteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation. |
| Storage: | -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing. |
*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.
Importance
Oxidative damage includes oxidative modification of cellular macromolecules, induction of cell death by apoptosis or necrosis, as well as structural tissue damage. Of the many biological targets of oxidative stress, lipids are the most involved class of biomolecules. Lipid oxidation gives rise to a number of secondary products of polyunsaturated fatty acid peroxidation. Malondialdehyde (MDA) is the principal and most studied product. Consistent evidence reveals the reaction between MDA and cellular macromolecules such as proteins, RNA and DNA (Valenzuela, 1991).
Numerous experiments have shown that MDA readily modifies proteins (Nair, 1986). MDA reacts with DNA to form adducts to deoxyguanosine and deoxyadenosine which may be mutagenic and these can be quantified in several human tissues (Marnett, 1999).This aldehyde is a highly toxic molecule and should be considered as a marker of lipid peroxidation. The interaction with DNA and proteins has often been referred to as potentially mutagenic and atherogenic (Rio et al., 2005).
L.J. Marnett, Lipid peroxidation‐DNA damage by malondialdehyde, Mutat Res, 424 (1999), pp. 83–95
V. Nair, C.S. Cooper, D.E. Vietti, G.A. Turner, The chemistry of lipid peroxidation metabolites: crosslinking reactions of malondialdehyde, Lipids, 21 (1986), pp. 6–10
Rio, Daniele Del, Amanda J. Stewart, and Nicoletta Pellegrini. "A Review of Recent Studies on Malondialdehyde as Toxic Molecule and Biological Marker of Oxidative Stress." Nutrition, Metabolism and Cardiovascular Diseases 15.4 (2005): 316-28.
A. Valenzuela, The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress, Life Sci, 48 (1991), pp. 301–309
Citations
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自1995年以来，Academy生物医学公司一直致力于以合理的价格向心血管和动脉粥样硬化研究领域提供高质量的抗体。我们很荣幸为科学界提供我们致力于脂蛋白，载脂蛋白领域研究的抗体和试剂。 ，以及它们的氧化改性产物。
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