![academy biomed/[A14]山羊抗人载脂蛋白E多克隆抗体/0.5 mg/50A-G1a](https://www.ebiomall.cn/images/academybiomed/A14_300x300.jpg)
academy biomed/[A14]山羊抗人载脂蛋白E多克隆抗体/0.5 mg/50A-G1a
商品编号：
50A-G1a
品牌：
academybiomed
市场价：
¥23340.00
美元价：
11670.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Host Species: | Goat |
| Concentration: | 1 mg/ml (OD 1.35 / 280 nm) |
| Antigen: | Human Apolipoprotein E |
| Purification: | Affinity purified |
| Buffer: | 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 |
| Specificity | Specifically binds to human apo E. Dilution for immunoblot and ELISA range: 1,000 to 8,0000. |
| Use: | The antibody can be used for detection of apo E in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation. |
| Storage: | -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing. |
*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.
Importance
Apo E contains 299 amino acid residues. It is a 34-37 kDa glycosylated protein (Rall et al., 1983).
Apo E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. Apo E has also been implicated in immune and nerve degeneration. It has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo E isoforms, Apo E4. The Apo E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.
Rall, S C, K H Weisgraber, T L Innerarity, T P Bersot, R W Mahley, and C B Blum. "Identification of a New Structural Variant of Human Apolipoprotein E, E2(Lys146 Leads to Gln), in a Type III Hyperlipoproteinemic Subject with the E3/2 Phenotype." Journal of Clinical Investigation 72.4 (1983): 1288-297.
Citations
| [A14] | 2020 | Liu, Gang; Zhang, Bo; Hu, Yang; Rood, Jennifer; Liang, Liming; Qi, Lu et al. (2020): Associations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study. In Environmental Health: a global access science source 19 (1), p. 5. DOI: 10.1186/s12940-020-0561-8. |
| [A14] | 2020 | Koch, Manja; DeKosky, Steven T.; Goodman, Matthew; Sun, Jiehuan; Furtado, Jeremy D.; Fitzpatrick, Annette L. et al. (2020): Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia. JAMA Network Open 3 (7), e209250. DOI: 10.1001/jamanetworkopen.2020.9250. |
| [A14] | 2020 | Koch, Manja; DeKosky, Steven T.; Goodman, Matthew; Sun, Jiehuan; Furtado, Jeremy D.; Fitzpatrick, Annette L. et al. (2020): High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia. J. Lipid Res. 61 (3), pp. 445–454. DOI: 10.1194/jlr.P119000473. |
| [A14] | 2019 | Morton, Allyson M.; Furtado, Jeremy D.; Mendivil, Carlos O.; Sacks, Frank M. (2019): Dietary unsaturated fat increases HDL metabolic pathways involving apoE favorable to reverse cholesterol transport. JCI Insight 4 (7). DOI: 10.1172/jci.insight.124620. |
| [A14] | 2019 | Rawat, Varun; Wang, Shaowei; Sima, Jian; Bar, Roni; Liraz, Ori; Gundimeda, Usha et al. (2019): ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes. The Journal of Neuroscience 39 (48), pp. 9611–9622. DOI: 10.1523/JNEUROSCI.1400-19.2019. |
| [A14] | 2018 | Koch, Manja; DeKosky, Steven T.; Fitzpatrick, Annette L.; Furtado, Jeremy D.; Lopez, Oscar L.; Kuller, Lewis H. et al. (2018): Apolipoproteins and Alzheimer"s pathophysiology. In Alzheimer"s & Dementia (Amsterdam, Netherlands) 10, pp. 545–553. DOI: 10.1016/j.dadm.2018.07.001. |
| [A14] | 2018 | Morton, Allyson M.; Koch, Manja; Mendivil, Carlos O.; Furtado, Jeremy D.; Tjønneland, Anne; Overvad, Kim et al. (2018): Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk. In JCI Insight 3 (4). DOI: 10.1172/jci.insight.98045. |
| [A14] | 2017 | Gillard, Baiba K.; Bassett, G. Randall; Gotto, Antonio M.; Rosales, Corina; Pownall, Henry J. (2017): Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester. In J. Biol. Chem. 292 (21), pp. 8864–8873. DOI: 10.1074/jbc.M117.781963. |
| [A14] | 2017 | Ikeda, Toru; Shinohata, Ryoko; Murakami, Masaaki; Hina, Kazuyoshi; Kamikawa, Shigeshi; Hirohata, Satoshi et al. (2017): A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements. In Clinica Chimica Acta; international journal of clinical chemistry 465, pp. 112–118. DOI: 10.1016/j.cca.2016.12.016. |
| [A14] | 2017 | Koch, Manja; Furtado, Jeremy D.; Falk, Kim; Leypoldt, Frank; Mukamal, Kenneth J.; Jensen, Majken K. (2017): Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma. In Alzheimer"s & Dementia (Amsterdam, Netherlands) 6, pp. 182–187. DOI: 10.1016/j.dadm.2017.01.007. |
| [A14] | 2017 | Wassef, Hanny; Bissonnette, Simon; Dufour, Robert; Davignon, Jean; Faraj, May (2017): Enrichment of Triglyceride-Rich Lipoproteins with Apolipoprotein C-I Is Positively Associated with Their Delayed Plasma Clearance Independently of Other Transferable Apolipoproteins in Postmenopausal Overweight and Obese Women. In J. Nutr. 147 (5), pp. 754–762. DOI: 10.3945/jn.116.242750. |
| [A14] | 2016 | Ma, Weilie; Lin, Margarita; Ding, Hang; Lin, Guorong; Zhang, Zhizhen (2016): β-COP as a Component of Transport Vesicles for HDL Apolipoprotein-Mediated Cholesterol Exocytosis. In PloS one 11 (3), e0151767. DOI: 10.1371/journal.pone.0151767. |
| [A14] | 2016 | Yassine, Hussein N.; Feng, Qingru; Chiang, Jiarong; Petrosspour, Larissa M.; Fonteh, Alfred N.; Chui, Helena C.; Harrington, Michael G. (2016): ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer"s Disease. In Journal of the American Heart Association 5 (2). DOI: 10.1161/JAHA.115.002886. |
| [A14] | 2015 | Nakato, Mitsuhiro; Matsuo, Michinori; Kono, Nozomu; Arita, Makoto; Arai, Hiroyuki; Ogawa, Jun et al. (2015): Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells. In J. Lipid Res. 56 (10), pp. 1880–1890. DOI: 10.1194/jlr.M058164. |
| [A14] | 2015 | Woltjer, Randall L.; Reese, Lindsay C.; Richardson, Brian E.; Tran, Huong; Green, Sarah; Pham, Thao et al. (2015): Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus. In Molecular Genetics and Metabolism 116 (4), pp. 289–297. DOI: 10.1016/j.ymgme.2015.10.012. |
| [A14] | 2014 | Miyazaki, Akari; Sagae, Nozomi; Usami, Yoko; Sato, Megumi; Kameda, Takahiro; Yoshimoto, Akira et al. (2014): N-homocysteinylation of apolipoprotein A-I impairs the protein’s antioxidant ability but not its cholesterol efflux capacity. In Biological Chemistry 395 (6). DOI: 10.1515/hsz-2013-0262. |
| [A14] | 2014 | Talayero, Beatriz; Wang, Liyun; Furtado, Jeremy; Carey, Vincent J.; Bray, George A.; Sacks, Frank M. (2014): Obesity favors apolipoprotein E- and C-III-containing high density lipoprotein subfractions associated with risk of heart disease. In J. Lipid Res. 55 (10), pp. 2167–2177. DOI: 10.1194/jlr.M042333. |
| [A14] | 2013 | Bissonnette, Simon; Salem, Huda; Wassef, Hanny; Saint-Pierre, Nathalie; Tardif, Annie; Baass, Alexis et al. (2013): Low density lipoprotein delays clearance of triglyceride-rich lipoprotein by human subcutaneous adipose tissue. In J. Lipid Res. 54 (5), pp. 1466–1476. DOI: 10.1194/jlr.P023176. |
| [A14] | 2013 | Sumner, Anne E.; Furtado, Jeremy D.; Courville, Amber B.; Ricks, Madia; Younger-Coleman, Novie; Tulloch-Reid, Marshall K.; Sacks, Frank M. (2013): ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women. In Nutrition & Metabolism 10 (1), p. 73. DOI: 10.1186/1743-7075-10-73. |
| [A14] | 2013 | Ulrich, Jason D.; Burchett, Jack M.; Restivo, Jessica L.; Schuler, Dorothy R.; Verghese, Philip B.; Mahan, Thomas E. et al. (2013): In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. In Molecular Neurodegeneration 8, p. 13. DOI: 10.1186/1750-1326-8-13. |
| [A14] | 2011 | Evans, Vanessa C.; Graham, Ian R.; Athanasopoulos, Takis; Galley, Deborah J.; Jackson, Christopher L.; Simons, Jonathan Paul et al. (2011): Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle. In Metabolism: clinical and experimental 60 (4), pp. 491–498. DOI: 10.1016/j.metabol.2010.04.015. |
| [A14] | 2011 | Kim, J.; Jiang, H.; Park, S.; Eltorai, A. E. M.; Stewart, F. R.; Yoon, H. et al. (2011): Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid- Amyloidosis. In Journal of Neuroscience 31 (49), pp. 18007–18012. DOI: 10.1523/JNEUROSCI.3773-11.2011. |
| [A14] | 2011 | Zhao, Wentao; Du, Fen; Zhang, Michelle; Sun, Shengfang; Yu, Hong; Fan, Daping (2011): A new recombinant human apolipoprotein E mimetic peptide with high-density lipoprotein binding and function enhancing activity. In Experimental Biology and Medicine (Maywood, N.J.) 236 (12), pp. 1468–1476. DOI: 10.1258/ebm.2011.011169. |
| [A14] | 2010 | Furtado, Jeremy D.; Campos, Hannia; Sumner, Anne E.; Appel, Lawrence J.; Carey, Vincent J.; Sacks, Frank M. (2010): Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial. In The American Journal of Clinical Nutrition 92 (4), pp. 714–722. DOI: 10.3945/ajcn.2009.28532. |
| [A14] | 2010 | Sundaram, Meenakshi; Zhong, Shumei; Khalil, Maroun Bou; Links, Philip H.; Zhao, Yang; Iqbal, Jahangir et al. (2010): Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions. In J. Lipid Res. 51 (1), pp. 150–161. DOI: 10.1194/jlr.M900346-JLR200. |
| [A14] | 2009 | Benyamini, Payam; Webster, Paul; Meyer, David I. (2009): Knockdown of p180 eliminates the terminal differentiation of a secretory cell line. In Molecular Biology of the Cell 20 (2), pp. 732–744. DOI: 10.1091/mbc.E08-07-0682. |
| [A14] | 2009 | Carmel, Jean-François; Tarnus, Evelyne; Cohn, Jeffrey S.; Bourdon, Emmanuel; Davignon, Jean; Bernier, Lise (2009): High expression of apolipoprotein E impairs lipid storage and promotes cell proliferation in human adipocytes. In J. Cell. Biochem. 106 (4), pp. 608–617. DOI: 10.1002/jcb.22037. |
| [A14] | 2009 | Korwek, Kimberly M.; Trotter, Justin H.; Ladu, Mary Jo; Sullivan, Patrick M.; Weeber, Edwin J. (2009): ApoE isoform-dependent changes in hippocampal synaptic function. In Molecular Neurodegeneration 4, p. 21. DOI: 10.1186/1750-1326-4-21. |
| [A14] | 2009 | Osman, Eyman; Evans, Vanessa; Graham, Ian R.; Athanasopoulos, Takis; McIntosh, Jenny; Nathwani, Amit C. et al. (2009): Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice. In Atherosclerosis 204 (1), pp. 121–126. DOI: 10.1016/j.atherosclerosis.2008.08.043. |
| [A14] | 2009 | Tarnus, Evelyne; Wassef, Hanny; Carmel, Jean-François; Rondeau, Philippe; Roche, Marjolaine; Davignon, Jean et al. (2009): Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes. In FEBS Letters 583 (12), pp. 2042–2048. DOI: 10.1016/j.febslet.2009.05.016. |
| [A14] | 2008 | Furtado, Jeremy D.; Campos, Hannia; Appel, Lawrence J.; Miller, Edgar R.; Laranjo, Nancy; Carey, Vincent J.; Sacks, Frank M. (2008): Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial. In The American Journal of Clinical Nutrition 87 (6), pp. 1623–1630. DOI: 10.1093/ajcn/87.6.1623. |
| [A14] | 2008 | Zeitouni, Suzanne; Ford, Brian S.; Harris, Sean M.; Whitney, Mandolin J.; Gregory, Carl A.; Prockop, Darwin J. (2008): Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs). In BMC Biotechnol 8 (1), p. 75. DOI: 10.1186/1472-6750-8-75. |
| [A14] | 2008 | Zheng, Chunyu; Khoo, Christina; Furtado, Jeremy; Ikewaki, Katsunori; Sacks, Frank M. (2008): Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. In The American Journal of Clinical Nutrition 88 (2), pp. 272–281. DOI: 10.1093/ajcn/88.2.272. |
| [A14] | 2007 | Fan, Daping; Qiu, Shenfeng; Overton, Cheryl D.; Yancey, Patricia G.; Swift, Larry L.; Jerome, W. Gray et al. (2007): Impaired secretion of apolipoprotein E2 from macrophages. In J. Biol. Chem. 282 (18), pp. 13746–13753. DOI: 10.1074/jbc.M611754200. |
| [A14] | 2006 | Kawakami, Akio; Aikawa, Masanori; Libby, Peter; Alcaide, Pilar; Luscinskas, Francis W.; Sacks, Frank M. (2006): Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. In Circulation 113 (5), pp. 691–700. DOI: 10.1161/CIRCULATIONAHA.105.591743. |
| [A14] | 2005 | Nedelkov, Dobrin; Kiernan, Urban A.; Niederkofler, Eric E.; Tubbs, Kemmons A.; Nelson, Randall W. (2005): Investigating diversity in human plasma proteins. In Proc Natl Acad Sci USA 102 (31), pp. 10852–10857. DOI: 10.1073/pnas.0500426102. |
| [A14] | 2003 | Niederkofler, Eric E.; Tubbs, Kemmons A.; Kiernan, Urban A.; Nedelkov, Dobrin; Nelson, Randall W. (2003): Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins. In J. Lipid Res. 44 (3), pp. 630–639. DOI: 10.1194/jlr.D200034-JLR200. |
| [A14] | 2003 | Takahashi, Y.; Itoh, F.; Oohashi, T.; Miyamoto, T. (2003): Distribution of apolipoprotein E among lipoprotein fractions in the lactating cow. In Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 136 (4), pp. 905–912. DOI: 10.1016/j.cbpc.2003.09.004. |
| [A14] | 2003 | Yang, Chao-Yuh; Raya, Joe L.; Chen, Hsin-Hung; Chen, Chu-Huang; Abe, Yasunori; Pownall, Henry J. et al. (2003): Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. In Arterioscler Thromb Vasc Biol. 23 (6), pp. 1083–1090. DOI: 10.1161/01.ATV.0000071350.78872.C4. |
品牌介绍
自1995年以来，Academy生物医学公司一直致力于以合理的价格向心血管和动脉粥样硬化研究领域提供高质量的抗体。我们很荣幸为科学界提供我们致力于脂蛋白，载脂蛋白领域研究的抗体和试剂。 ，以及它们的氧化改性产物。
联络我们
