![academy biomed/[A05]绵羊抗人载脂蛋白AII多克隆抗体/0.5 mg/12A-S1a](https://www.ebiomall.cn/images/academybiomed/A05_300x300.jpg)
academy biomed/[A05]绵羊抗人载脂蛋白AII多克隆抗体/0.5 mg/12A-S1a
商品编号：
12A-S1a
品牌：
academybiomed
市场价：
¥3100.00
美元价：
1550.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Host Species: | Sheep |
| Concentration: | 1 mg/ml (OD 1.35 / 280 nm) |
| Antigen: | Human Apolipoprotein AII |
| Purification: | Affinity purified |
| Buffer: | 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 |
| Specificity | Specifically binds to human apo AII. Dilution for immunoblot and ELISA range: 1,000 to 80,000. |
| Use: | The antibody can be used for detection of apo AII in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation. |
| Storage: | -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing. |
*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.
Importance
Apo AII comprises 25% of HDL. It exists in human plasma as a dimer of 2 identical chains of 77 amino acid residues, joined by disulfide. The molecular weight is reported to be 8.7 kDa for a single chain (Brewer et al., 1972).
Studies on mouse reported that apoAII may be proatherogenic (Warden et al., 1993); however, case-control study in the large European Prospective Investigation demonstrated that plasma Apo AII concentrations were strongly inversely correlated with CHD events (Birjmohun et al., 2007).
Birjmohun, R. S., G. M. Dallinga-Thie, J. A. Kuivenhoven, E. S.g. Stroes, J. D. Otvos, N. J. Wareham, R. Luben, J. J.p. Kastelein, K.-T. Khaw, and S. M. Boekholdt. "Apolipoprotein A-II Is Inversely Associated With Risk of Future Coronary Artery Disease." Circulation 116 (2007): 2029-035.
Brewer, H. B., S. E. Lux, R. Ronan, and K. M. John. "Amino Acid Sequence of Human ApoLp-Gln-II (apoA-II), an Apolipoprotein Isolated from the High-Density Lipoprotein Complex." Proceedings of the National Academy of Sciences 69.5 (1972): 1304-308.
Warden, C., C. Hedrick, J. Qiao, L. Castellani, and A. Lusis. "Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II." Science 261 (1993): 469-72.
Citations
| [A04][A05][A06] | 2020 | Lee, An-Sheng; Wang, Yu-Chen; Chang, Shih-Sheng; Lo, Ping-Hang; Chang, Chia-Ming; Lu, Jonathan et al. (2020): Detection of a High Ratio of Soluble to Membrane-Bound LOX-1 in Aspirated Coronary Thrombi From Patients With ST-Segment-Elevation Myocardial Infarction. Journal of the American Heart Association 9 (2), e014008. DOI: 10.1161/JAHA.119.014008. |
| [A04][A05][A06] | 2017 | Gillard, Baiba K.; Bassett, G. Randall; Gotto, Antonio M.; Rosales, Corina; Pownall, Henry J. (2017): Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester. In J. Biol. Chem. 292 (21), pp. 8864–8873. DOI: 10.1074/jbc.M117.781963. |
| [A04][A05][A06] | 2017 | Ikeda, Toru; Shinohata, Ryoko; Murakami, Masaaki; Hina, Kazuyoshi; Kamikawa, Shigeshi; Hirohata, Satoshi et al. (2017): A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements. In Clinica Chimica Acta; International Journal of Clinical Chemistry 465, pp. 112–118. DOI: 10.1016/j.cca.2016.12.016. |
| [A04][A05][A06] | 2016 | Azizkhanian, Ida; Trenchevska, Olgica; Bashawri, Yara; Hu, Jiaqi; Koska, Juraj; Reaven, Peter D. et al. (2016): Posttranslational modifications of apolipoprotein A-II proteoforms in type 2 diabetes. In Journal of Clinical Lipidology 10 (4), pp. 808–815. DOI: 10.1016/j.jacl.2016.03.001. |
| [A04][A05][A06] | 2015 | Kameda, Takahiro; Ohkawa, Ryunosuke; Yano, Kouji; Usami, Yoko; Miyazaki, Akari; Matsuda, Kazuyuki et al. (2015): Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein. In Journal of Lipids 2015 (9), pp. 1–8. DOI: 10.1155/2015/592594. |
| [A04][A05][A06] | 2014 | Miyazaki, Akari; Sagae, Nozomi; Usami, Yoko; Sato, Megumi; Kameda, Takahiro; Yoshimoto, Akira et al. (2014): N-homocysteinylation of apolipoprotein A-I impairs the protein’s antioxidant ability but not its cholesterol efflux capacity. In Biological Chemistry 395 (6). DOI: 10.1515/hsz-2013-0262. |
| [A04][A05][A06] | 2012 | Kameda, Takahiro; Usami, Yoko; Shimada, Saki; Haraguchi, Go; Matsuda, Kazuyuki; Sugano, Mitsutoshi et al. (2012): Determination of myeloperoxidase-induced apoAI-apoAII heterodimers in high-density lipoprotein. In Annals of Clinical and Laboratory Science 42 (4), pp. 384–391. |
| [A04][A05][A06] | 2011 | Holmberg, R.; Refai, E.; Hoog, A.; Crooke, R. M.; Graham, M.; Olivecrona, G. et al. (2011): Lowering apolipoprotein CIII delays onset of type 1 diabetes. In J. Biol. Chem. 108 (26), pp. 10685–10689. DOI: 10.1073/pnas.1019553108. |
| [A04][A05][A06] | 2011 | Sakamoto, Haruhiko; Wu, Bin; Nagai, Yumiko; Tanaka, Sumiko; Onodera, Masayuki; Ogawa, Takafumi; Ueno, Masaki (2011): Platelet high-density lipoprotein activates transferrin-derived phagocytosis activators, MAPPs, following thrombin digestion. In Platelets 22 (5), pp. 371–379. DOI: 10.3109/09537104.2010.533797. |
| [A04][A05][A06] | 2008 | Deng, Ting; Ji, Wei; Lian, Ji-Hong; Guo, Lei; Hu, Wei-Rong; Qian, Ming; Gong, Bang-qiang (2008): Identifying Natural Derived Upregulators of Human ApoA-I Expression via a Cell-Based Drug Screening System. In Pharmaceutical Biology 46 (9), pp. 610–615. DOI: 10.1080/13880200802179584. |
| [A04][A05][A06] | 2006 | Guo, Lei; Hu, Wei-Rong; Lian, Ji-Hong; Ji, Wei; Deng, Ting; Qian, Ming; Gong, Bang-qiang (2006): Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivo. In European Journal of Pharmacology 551 (1-3), pp. 80–86. DOI: 10.1016/j.ejphar.2006.08.048. |
| [A04][A05][A06] | 2006 | Thompson, Patricia A.; Kitchens, Richard L. (2006): Native high-density lipoprotein augments monocyte responses to lipopolysaccharide (LPS) by suppressing the inhibitory activity of LPS-binding protein. In J.I. 177 (7), pp. 4880–4887. DOI: 10.4049/jimmunol.177.7.4880. |
| [A04][A05][A06] | 2005 | Nedelkov, Dobrin; Kiernan, Urban A.; Niederkofler, Eric E.; Tubbs, Kemmons A.; Nelson, Randall W. (2005): Investigating diversity in human plasma proteins. In Proc Natl Acad Sci USA 102 (31), pp. 10852–10857. DOI: 10.1073/pnas.0500426102. |
| [A04][A05][A06] | 2004 | Ogasawara, Ken; Mashiba, Shinichi; Wada, Youichiro; Sahara, Makoto; Uchida, Kazuo; Aizawa, Tadanori; Kodama, Tatsuhiko (2004): A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease. In Atherosclerosis 174 (2), pp. 349–356. DOI: 10.1016/j.atherosclerosis.2004.01.030. |
| [A04][A05][A06] | 2003 | Niederkofler, Eric E.; Tubbs, Kemmons A.; Kiernan, Urban A.; Nedelkov, Dobrin; Nelson, Randall W. (2003): Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins. In J. Lipid Res. 44 (3), pp. 630–639. DOI: 10.1194/jlr.D200034-JLR200. |
| [A04][A05][A06] | 2001 | Yuhanna, I. S.; Zhu, Y.; Cox, B. E.; Hahner, L. D.; Osborne-Lawrence, S.; Lu, P. et al. (2001): High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. In Nature Medicine 7 (7), pp. 853–857. DOI: 10.1038/89986. |
品牌介绍
自1995年以来，Academy生物医学公司一直致力于以合理的价格向心血管和动脉粥样硬化研究领域提供高质量的抗体。我们很荣幸为科学界提供我们致力于脂蛋白，载脂蛋白领域研究的抗体和试剂。 ，以及它们的氧化改性产物。
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