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| Host Species: | Sheep |
| Concentration: | 1 mg/ml (OD 1.35 / 280 nm) |
| Antigen: | Human Apolipoprotein (a) |
| Purification: | Affinity purified |
| Buffer: | 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 |
| Specificity | Specifically binds to human Lp (a) and apo (a). No cross- reaction to Apo B-100/48; minor to plasminogen. Dilution for immunoblot and ELISA range: 1,000 to 80,000. |
| Use: | The antibody can be used for detection of human albumin in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation. |
| Storage: | -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing. |
*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.
Importance
The Lipoprotein (a) [Lp(a)] structure is similar to that of low density lipoprotein (LDL), regarding size and lipid composition of the particles and the presence of apolipoprotein B-100 (apo B-100). In addition to apo B-100, Lp(a) has a second protein, apolipoprotein (a) [apo (a)], which the molecular weight of that glycoprotein varies widely from 400 to 700 kDa. (Maranhão et al., 2013)
Previous research has shown that apo (a) has a similar structure with plasminogen and contains a serine protease domain and two types of plasminogen-like kringle domains. (McLean et al., 1987) The plasma concentration of human lipoprotein[a], Lp[a], is highly correlated with coronary artery disease. (Gaubatz et al., 1990)
Gaubatz, J.W., K. I. Ghanem, J. Jr. Guevara, M. L. Nava, W. Patsch, and J. D. Morrisett. “Polymorphic forms of human apolipoprotein[a]: inheritance and relationship of their molecular weights to plasma levels of lipoprotein[a].” J. Lipid Res. 31.4 (1990):603-13.
Mclean, John W., James E. Tomlinson, Wun-Jing Kuang, Dan L. Eaton, Ellson Y. Chen, Gunther M. Fless, Angelo M. Scanu, and Richard M. Lawn. "CDNA Sequence of Human Apolipoprotein(a) Is Homologous to Plasminogen." Nature 330.6144 (1987): 132-37.
Maranhão, Raul Cavalcante, Priscila Oliveira Carvalho, Celia Cassaro Strunz, and Fulvio Pileggi. "Lipoprotein (a): Structure, Pathophysiology and Clinical Implications." Arquivos Brasileiros De Cardiologia 103.1 (2014): 76-84.
